Synthesis and Characterization of Indazol-3-one and Thioxo Pyrimidines Derivatives from Mono and Twin Chalcones

Abstract

This work involved synthesis and characterization of new mono and twin fused pyrazolone(indazol-3-one) (IV)_a-d and thioxo pyrimidine (III)_a-d  derivatives from Chalcones (mono(I)_a,b and twin(I)_c,d ) The synthesis of mono chalcones (I)_a,b  includes the reaction of  (p-methoxy or p- methyl) benzaldehyde with 4-amino acetophenone while the twin acetophenone with p- methoxy benzaldehyde to produce twin chalcones (I)_c,d , then converted it by Robinson annulations reaction to form the corresponding derivatives (II)_a-d afterward  reflux the cyclohexenones with hydrazine and some drops of GAA lead to form indazole derivatives (IV)_a-d . Pyrimidines were synthesized via the reaction of chalcones with thiourea in NaOH and 80% ethanol. All these compounds are characterized by FT-IR spectroscopy and some of them by ¹HNMR spectroscopy.