Synthesis and Characterization of Indazol-3-one and Thioxo Pyrimidines Derivatives from Mono and Twin Chalcones

  • Thaer Saleh Ghali Department of Chemistry, College of Education for Pure Science(Ibn Al-Haitham), University of Baghdad. Baghdad-Iraq.
  • Jumbad Hermiz Tomma Department of Chemistry, College of Education for Pure Science(Ibn Al-Haitham), University of Baghdad. Baghdad-Iraq.
Keywords: Chalcones, Heterocyclic, cyclohexenone, pyrimidine, indazole

Abstract

This work involved synthesis and characterization of new mono and twin fused pyrazolone(indazol-3-one) (IV)a-d and thioxo pyrimidine (III)a-d  derivatives from Chalcones (mono(I)a,b and twin(I)c,d ) The synthesis of mono chalcones (I)a,b  includes the reaction of  (p-methoxy or p- methyl) benzaldehyde with 4-amino acetophenone while the twin acetophenone with p- methoxy benzaldehyde to produce twin chalcones (I)c,d , then converted it by Robinson annulations reaction to form the corresponding derivatives (II)a-d afterward  reflux the cyclohexenones with hydrazine and some drops of GAA lead to form indazole derivatives (IV)a-d . Pyrimidines were synthesized via the reaction of chalcones with thiourea in NaOH and 80% ethanol. All these compounds are characterized by FT-IR spectroscopy and some of them by 1HNMR spectroscopy.

Published
2018-01-08
How to Cite
Ghali, T. S., & Tomma, J. H. (2018). Synthesis and Characterization of Indazol-3-one and Thioxo Pyrimidines Derivatives from Mono and Twin Chalcones. Iraqi Journal of Science, 58(4C), 2265-2277. Retrieved from https://ijs.uobaghdad.edu.iq/index.php/eijs/article/view/29
Section
Chemistry