Synthesis & Characterization of Some 1, 3, 4-OxadiazoleDerivatives & new Cyclic Imides from Creatinine

Abstract

A series of new 1,3,4- oxadiazole derivatives and cyclic Imides containing Creatinine
heterocyclic molecule were prepared via following method:first step included Synthesis of
amic acid from reaction between different cyclic anhydrides with Creatinine which
subsequently dehydrated to the corresponding imide via treatment with acetic anhydride
and anhydrous sodium acetate,.then,second step was tratedamic acid with Thionyl chloride
producing acid chloride which on amination with hydrazine hydrate in thierd step and the
last turn to 1,3,4-oxadiazole derivatives by condensation reaction with Phosphorous
Oxychloride(POCl3) and different benzoic acids. Cyclization to 1, 3, 4-Oxadiazole
derivatives. Antibacterial activity of some prepared new compounds against two types of
bacteria were evaluated and result showed the new exhibit good moderate antibacterial
activity.Prepared compounds were elucidated on the basis FT-IR,1H-NMR and MASS
spectro data which agreed with the proposed structures.