Synthesis, Identification and Biological Activity Study of Some New Spiro-Isatin Derivatives

Authors

  • Farah N. Faisal Department of Chemistry, College of Science, University of Baghdad Al-Jadriya Campus, Baghdad 10071, Iraq
  • Rafid S. Dawood Department of Chemistry, College of Science, University of Baghdad Al-Jadriya Campus, Baghdad 10071, Iraq https://orcid.org/0000-0002-7412-0019

DOI:

https://doi.org/10.24996/ijs.2024.65.4.5

Keywords:

Antioxidant activity, Isatin, Imidazolidone ring, Spiro-compounds

Abstract

     Spiro-isatin derivatives have been the subject of extensive research due to their diverse pharmacological properties and potential therapeutic applications. These molecules are characterized by a spirocyclic structure that includes an isatin moiety and one or more heterocyclic rings, resulting in a unique and versatile molecular architecture. In this work, a series of new spiro-isatin derivatives B1-12 were synthesized over two steps. The first step included a condensation reaction between isatin and various aromatic amines, affording the corresponding Schiff bases A1-12 in high yields (up to 96%). In the second step, A1-12 underwent a reaction with glycine, resulting in the formation of B1-12 with yields varying between 65 and 92%. The structures of the compounds were confirmed by FT-IR and 1H NMR spectroscopy. A few of the produced compounds were examined for antibacterial and antioxidant properties. 

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Chemistry

How to Cite

Synthesis, Identification and Biological Activity Study of Some New Spiro-Isatin Derivatives. (n.d.). Iraqi Journal of Science, 65(4). https://doi.org/10.24996/ijs.2024.65.4.5