Study Antibacterial Activity of Crude Capparis spinosa L. Extracts Against Helicobacter pylori Infection and Determine Their Bioactive Compounds

Manar F. Jassim Al-Khafagi; Dina Yousif Mohammed

doi:10.24996/ijs.2023.64.2.1

Authors

Manar F. Jassim Al-Khafagi Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
Dina Yousif Mohammed Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq https://orcid.org/0000-0002-7303-3562

DOI:

https://doi.org/10.24996/ijs.2023.64.2.1

Keywords:

Capparis spinosa, Helicobacter pylori, Ethanol extracts, Antibacterial, Gastric ulcer

Abstract

The antibacterial activity of Capparis spinosa L. extracts obtained from Baghdad was evaluated against six clinical bacteria isolates of Helicobacter pylori. The results presented in this work demonstrated that the leaves extract showed a significant effect against bacteria as compared to the root and fruit extracts at 100 mg/ml concentration, with inhibition zone ranging from 12.0 to 30.7 mm in each bacteria strain. The end results of GC-MS analysis indicated that the ethanol extracts of caper have a lot of active chemical compounds, including twenty-five, eighty-two and sixty-eight phytoconstituent compounds, that are distinguished in the extracts of roots, leaves and fruits with C. spinosa L. respectively. In addition, the high area % revealed in each extracts were: 1-methyl-pyrrolidine-2-carboxylic acid 35.77%, prolin, N-methyl-, butyl ester 12, 63% and (23S)-ethylcholest-5-en-3.beta.-ol 19.12% respectively.