Synthesis, Characterization and Anticancer Activity of polyether Derived from Polyvinyl Alcohol with New benzothiazole Derivatives in Treatment of Liver Cancer Cell line hepG2

Abstract

A novel benzothiazole derivative compound, [M1], was synthesized by reacting 4-aminoacetophenone with 2-aminobenzothiazole in the presence of glacial acetic acid as a catalyst, enabling the efficient formation of the target compound. Amic acid compounds [M2-M4] were synthesized from the reaction of compound [M1] with various cyclic anhydrides in dry acetone. Cyclic imides derivatives were synthesized by a dehydrated reaction of the prepared amic acid [M2-M4] with acetic anhydride and sodium acetate to produce the corresponding cyclic imides [M5-M7]. The synthesized compounds [M5-M7] reacted with Acetyl chloride to produce the corresponding acetamide derivatives compounds [M8-M10]. The polyether derivatives [M11-M13] were synthesized from the reaction of polyvinyl alcohol with compounds [M8-M10]. All prepared compounds were characterized using infrared spectroscopy FTIR and nuclear magnetic resonance NMR spectroscopy for some of them. The in vitro anticancer efficacy of compound M12 was assessed against the liver cancer cell line hepG2, providing valuable insights into its potential as a therapeutic agent against liver cancer.