Synthesis, Characterization and Anticancer Activity of polyester Derived from Polyvinyl Alcohol with New Oxazolidine-5-one Derivatives

Elaf Noori  Talib; Maha A. Younus

doi:10.24996/ijs.2025.66.10.1

Authors

Elaf Noori Talib Department of Chemistry, College of Science, University of Baghdad, Iraq
Maha A. Younus Department of Chemistry, College of Education for Pure Sciences (Ibn al-Haytham), University of Baghdad

DOI:

https://doi.org/10.24996/ijs.2025.66.10.1

Keywords:

Liver anticancer, Oxazolidinone, Polyester, Polyvinyl alcohol

Abstract

In this study, compound [A], an oxime derivative, was synthesized through the reaction of 4-aminoacetophenone with hydroxylamine hydrochloride, using sodium acetate as a catalyst. Subsequently, Schiff bases [A1-A3] were prepared by reacting compound [A] with various aromatic aldehydes in the presence of glacial acetic acid. Acid derivatives containing oxazolidinone ring [A4- A6] were synthesized from the reaction of Schiff bases [A1- A3] with chloroacetic acid. The resulting compounds [A4-A6] reacted with thionyl chloride to produce the corresponding acid chloride [A7-A9]. Polyesters [A10-A12] were produced by reacting polyvinyl alcohol with compounds [A7-A9]. All prepared compounds were characterized using infrared spectroscopy FTIR and nuclear magnetic resonance NMR spectroscopy. Additionally, the anticancer activity of some of the prepared compounds (A10, A12) against liver cancer cell line hepG2 was evaluated in vitro.