Association of SCARB1 Gene Expression with Chronic Myeloid Leukemia Progression in a Sample of Iraqi Patients

Abstract

     The present research design examines the relationship between SCARB1 gene expression and the progression of chronic myeloid leukemia (CML) in Iraqi patients. The variations in gene expression between patients with CML and healthy controls were investigated. The gender and age correlations with CML patients were included, as was the association of gene expression folding of the SCARB1 gene with clinical data (WBC, RBC, hemoglobin, platelets, and BCR-ABL gene). The results displayed a significant difference in the mean gene expression level (∆Ct) of the CML group when compared to the matching ∆Ct values in the healthy control group. The gene expression folding of the SCARB1 gene indicates considerable changes in expression, which reached 0.134. There was no significant correlation for CML patients in regards to their age or gender, and with all studied clinical parameters except WBC and the BCR-ABL gene, there was no significant correlation. Our findings suggest that the degree of SCARB1 gene expression may serve as a determinant biomarker for CML prognosis.