Genetic Polymorphism of TLR5 and TLR6 in Iraqi Patients with Heart Failure Disease

Abstract

       In spite of the high rate of morbidity and mortality heart failure (HF) is common, and none of the medications are now entirely available for HF treatment. In addition to many environmental influences and clinical diseases, genetic factors may also contribute to the progression and development of HF.  In the current study, samples of blood were collected from 150 heart failure patients and 130 healthy controls. We evaluated the association of four single nucleotide polymorphisms (snps) of Toll-like receptors (TLR6 and TLR5) with (HF) susceptibility in the Iraqi population. In this work, (SNP) called Toll-like receptor 5 (rs5744168, rs2072493) and Toll-like receptor 6 (rs1039559, rs5743810) were employed. (PCR-RFLP) for snps (rs5744168, rs2072493, and re5743810), and sequencing for snps were used to assess the allele and genotype frequencies in both the patient and control groups (rs1039559). In patients with heart failure and healthy controls, a significant difference was discovered in the genotypic and allelic frequencies of snps. From our results, we suggest that these snps act as a potential predisposing factor for HF development.