Anti-Breast Cancer Activity of Some Synthesized Pyrazole Derivatives Bearing Imidazo[1,2a]pyridine Moiety

Authors

  • Amera H. Hamd Department of chemistry, college of science, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0002-8215-6433
  • Naeemah Al-Lami Department of chemistry, college of science, University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.24996/ijs.2023.64.7.1

Keywords:

Chalcones, [1,2a]imidazo pyridine, Pyrazole, Anticancer

Abstract

     A novel series of pyrazole derivatives containing imidazo[1,2-a]pyridine D1-D8 moiety has been synthesized. The reaction of 2-aminopyridine with 4-phenylphenacyl bromide and 4-bromophenacyl bromide gave the products A and A1, respectively. These products then reacted with DMF and POCl3 to obtain new aldehyde derivatives B and B1. These two aldehydes were condensed with various acetophenone substitutes to yield the corresponding chalcone derivatives C1-C10. Following this, the cycloaddition reaction with hydrazine hydrate provided new pyrazole derivatives D1-D8. The prepared compounds were verified by FT-IR, 1H NMR, and 13C NMR spectroscopy. Two of these derivatives (C5 and D1) were chosen to investigate their cytotoxic efficacy against breast cancer using the MTT assay.

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Published

2023-07-30

Issue

Section

Chemistry

How to Cite

Anti-Breast Cancer Activity of Some Synthesized Pyrazole Derivatives Bearing Imidazo[1,2a]pyridine Moiety. (2023). Iraqi Journal of Science, 64(7), 3205-3217. https://doi.org/10.24996/ijs.2023.64.7.1

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