Synthesis of New Oxopyrimidine and Cyanopyridine Derivatives Containing the Pyrimidine Benzothiazole Moiety with the Evaluating their Colon Anticancer Bioactivity

Authors

  • Abdul Gabar Abdul Maged Department of Chemistry, College of Science, University of Baghdad, Bagdad, Iraq https://orcid.org/0000-0003-2538-6010
  • Naeemah AL-Lami Department of Chemistry, College of Science, University of Baghdad, Bagdad, Iraq

DOI:

https://doi.org/10.24996/ijs.2023.64.8.1

Keywords:

Imidazo, Pyrimidine, Chalcone, Oxopyrimidine, Cyanopyridine, Colon anticancer, CaCo-2

Abstract

     In this contribution, new derivatives of bicyclic fused rings with bridgehead nitrogen of 3-substituted imidazo/pyrimidine derivatives A1-A3 were synthesized by reacting 2-aminobenzothiazol, acetyl acetone, and different substituted aldehydes in a one-pot reaction. These compounds A1-A3 were then condensed with 4-bromobenzaldehyde and 4-(N,N-dimethylamino)benzaldehyde to form new chalcone derivatives A4-A9. Ring closure of these compounds A4-A9 with urea and malononitrile afforded new oxopyrimidine derivatives A10-A15 and cyanopyridine derivatives A16-A21, respectively. These compounds were characterized by FT-IR, 1H NMR, and 13C NMR spectroscopy. The second part of this work included some of the important applications conducted for these compounds to evaluate their biological activities against colon cancer, which showed excellent results against this disease.

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Published

2023-08-30

Issue

Section

Chemistry

How to Cite

Synthesis of New Oxopyrimidine and Cyanopyridine Derivatives Containing the Pyrimidine Benzothiazole Moiety with the Evaluating their Colon Anticancer Bioactivity. (2023). Iraqi Journal of Science, 64(8), 3725-3734. https://doi.org/10.24996/ijs.2023.64.8.1

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