Evaluation of Synergistic Effect of Nicotinic Acid with Imipenem as Antibiofilm for Clinical Pseudomonas Aeruginosa Isolates

  • Sara A. Fayyad Department of Biotechnology, College of Science, University of Baghdad, Baghdad, Iraq
  • Majid R. Majeed Department of Biotechnology, College of Science, University of Baghdad, Baghdad, Iraq
  • Suhad S. Mahmoud Department of Biotechnology, College of Science, University of Baghdad, Baghdad, Iraq
Keywords: Anti-biofilm, Imipenem, Nicotinic acid, P.aurginosa

Abstract

The present study aims to evaluate the synergistic activity of nicotinic acid (NIC) with the Imipenem (IMI) as an anti-biofilm for clinical isolated Pseudomonas aeruginosa. The values of minimum inhibitor concentration (MICs) for IMI and NIC (Separately) against P. aeruginosa were (16) ug/mL and (8) ug/ml respectively. Whereas, the concentration of NIC with IMI (as combined) for biofilm inhibition was  1 ug/ml for NIC and 4 ug/ml for IMI. The combining of NIC with IMI showed synergistic efficacy against formation of bacterial biofilm (at MIC levels). These     results provide a conclusion that NIC combined with IMI is can be considered as a successful prospective treatment against the biofilm produced by P. aeruginosa and as antibacterial medication.

Published
2019-01-28
How to Cite
Fayyad, S. A., Majeed, M. R., & Mahmoud, S. S. (2019). Evaluation of Synergistic Effect of Nicotinic Acid with Imipenem as Antibiofilm for Clinical Pseudomonas Aeruginosa Isolates. Iraqi Journal of Science, 60(1), 50-56. Retrieved from https://ijs.uobaghdad.edu.iq/index.php/eijs/article/view/599
Section
Biotechnology