Investigation of Secondary Acute Lymphoblastic Leukemia (sALL) Among Acute Lymphoblastic Leukemia (ALL) Iraqi Patients

Abstract

Acute lymphoblastic leukemia which developed after first primary solid organ malignancy (1M) considered as secondary acute lymphoblastic leukemia (sALL) and it is rare. The observational study that researches for(sALL) in worldwide and even in Iraq is limited. This study investigated (sALL) among 50 (ALL) Iraqi patients (30 children; 20 adults). Five (4 female;1 male) out of  50 (ALL) patients (10%) were with(sALL) .They asked through questionnaire form about their age , 1M , latency period and immunophenotype .They were in 14-40 years age group and with previous malignancies breast , ovary, lung and thyroid cancers. The median latency period (from 1M to sALL) was 30 months. Four of (sALL) were with B cell immunophenotype , while one was with T cell. This observational study gives an evidence of the present of (sALL) among (ALL)  Iraqi patients after 1M in the adults . Since it is the first time to address the idea of this review article and has not been addressed previously, there is a need for a wide approach on this group of  (sALL)  patients,  including surveillance epidemiology , molecular and cytogenetic study.