Diffuse Thyroid Uptake in FDG PET/ CT Scan cCan Predict Subclinical Thyroid Disorders

Authors

  • Mustafa R. Hasan Department of Physics, College of Science University of Baghdad, Baghdad, Iraq
  • Satar M. Kadam Surgery Department, College of Medicine, University of Baghdad, Baghdad, Iraq
  • Samar I. Essa Department of Physics, College of Science University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.24996/ijs.2022.63.5.15

Keywords:

Diffuse thyroid uptake, hyperthyroidism, positron emission tomography, 18F-Fluorodeoxyglucose

Abstract

     Background: 18F-FDG positron emission tomography (PET) has established itself in the field of oncology and it is useful in the initial staging and follow-up of a variety of malignancies. Significant thyroid uptake is often identified as an accidental finding on whole-body positron emission tomography for non-thyroid disease.

Aim of this study: to investigate the effect of 18F-FDG on thyroid gland function after performing PET scan compared to thyroid function prior to scan.

Materials and Methods:  43 subjects who had an 18F-FDG PET scan as part of a cancer screening program participated in this study. All cancers  are diagnosed using 18F-FDG, except for prostate cancer, brain cancer and neuro-endocrine tumors, which  are diagnosed using Ga-68. Thyroid stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) were measured.

Results: Clinical information and results of thyroid function tests were available for 43 patients. Twenty- three out of 43 patients (53.48%) had abnormally high TSH levels with incident hypothyroidism, while 20 out of 43 patients (46.51%) had abnormally low TSH levels with incident hyperthyroidism, and the association was significant (p <0.05).

Conclusion: Thyroid hormone abnormality is strongly associated with the degree of diffuse thyroid uptake on 18F-FDG PET. As a result, an autoimmune process could be the most likely pathological cause of diffuse thyroid uptake.

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Published

2022-05-25

How to Cite

Hasan, M. R. ., Kadam, S. M. ., & Essa, S. I. . (2022). Diffuse Thyroid Uptake in FDG PET/ CT Scan cCan Predict Subclinical Thyroid Disorders. Iraqi Journal of Science, 63(5), 2000–2005. https://doi.org/10.24996/ijs.2022.63.5.15

Issue

Section

Physics