Study of β-Catenin as Immunohistochemistry Marker in Women with Breast Cancer

  • Ruqayah Ali Salman Department of Medical Laboratory Techniques, Al-Mussaib Technical Institute, Al-Furat Al-Awsat Technical University,51009
  • Genan Adnan Abdullatef AlBairuty Department of Microbiology, College of Science, Al-Karkh University of Science
  • Omar F. Abdul-Rasheed Departement of chemistry and Biochemistry, College of Medicine, Al-Nahrain University
Keywords: β-catenin, breast cancer, Tumor markers

Abstract

Background & Objective: Breast cancer (BC) is the most prevalent disease among women around the world, considered the world's leading cause of death (15% of the total cancer deaths) in women in 2018. β-catenin is a multifunctional protein located in the cytoplasm and/or nucleus of the cell. Several studies suggested that β-catenin expression plays a critical role in cancer invasion and metastasis. This research sought to examine β-catenin expression in breast cancer and its associations with clinico-pathological features (such as histopathological types, grade, and invasion depth of tumor as well as lymph node involvement) and breast cancer patient survival. Methods: The study was performed in the period from 1 January to July 2019 on 40 female breast cancer patients. The control group involved 40 healthy females with no history of cancer. Tissue blocks from histologically confirmed patient and control subjects were fixed in formalin and embedded in paraffin . β-catenin was evaluated by immunohistochemistry (IHC). Results: The immunohistochemical study of the subcellular localization of β-catenin demonstrated that 75% of the patients showed 1-3 score for β- catenin compared to only 27.5% of controls who had such score, with a highly significant difference. Conclusions: The use of β-catenin IHC markers can be effective throughout the treatment of progressive BC.

Published
2021-02-26
How to Cite
Salman, R. A., AlBairuty, G. A. A., & Abdul-Rasheed, O. F. (2021). Study of β-Catenin as Immunohistochemistry Marker in Women with Breast Cancer . Iraqi Journal of Science, 62(2), 387-395. https://doi.org/10.24996/ijs.2021.62.2.4
Section
Biology