CYTOTOXICITY OF NON-BOUND COLICINS EXTRACTED FROMEscherichia coil ON NORMAL WHITE BLOOD CELLS ANDMYELOBLAST ISOLATED FROM ACUTE MYELOID LEUKEMIABLOOD PATIENTS

Hind  Obaid; Rajwa   Essa; Nahiy   Yaseen

doi:10.24996/ijs.2010.51.4.%g

CYTOTOXICITY OF NON-BOUND COLICINS EXTRACTED FROMEscherichia coil ON NORMAL WHITE BLOOD CELLS ANDMYELOBLAST ISOLATED FROM ACUTE MYELOID LEUKEMIABLOOD PATIENTS

Authors

Hind Obaid Department of Biology, College of Science, University of Baghdad, Baghdad - Iraq.
Rajwa Essa Department of Biology, College of Science, University of Al-Mustansiyria, Baghdad - Iraq
Nahiy Yaseen University of Al-Mustansiyria, Iraqi Center of Cancer and Genetic medicine, Baghdad - Iraq

DOI:

https://doi.org/10.24996/ijs.2010.51.4.%25g

Keywords:

CYTOTOXICITY, COLICINS, coil

Abstract

Four types of non-bound colicins (H٥, H٩, H١٣, H١٩) were extracted from
intestinal normal flora Escherichia coil isolated from healthy people’s stool. Then
study cytotoxic effect of colicins on normal white blood cells (WBCs) from healthy
people. And cytotoxicity on myeloblasts isolated from AML patients blood. Results
showed, myeloblasts from AML patients were more sensitive to colicins than
normal WBCs from healthy people.The toxic effect was dose-dependent and
exposure time.

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Published

2024-09-27

Issue

Vol. 51 No. 4 (2010)

Section

Biology

License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

CYTOTOXICITY OF NON-BOUND COLICINS EXTRACTED FROMEscherichia coil ON NORMAL WHITE BLOOD CELLS ANDMYELOBLAST ISOLATED FROM ACUTE MYELOID LEUKEMIABLOOD PATIENTS. (2024). Iraqi Journal of Science, 51(4), 528-538. https://doi.org/10.24996/ijs.2010.51.4.%g