The Impact of The Hormone Profile of Reproductive Technology Outcomes in Women Undergoing Gonadotropin-Releasing Hormone

Abstract

     Hormones greatly influence women's health. A variety of factors can bring on women's hormonal imbalances. The understanding of the origins and diagnosis of female infertility has been viewed as being highly dependent on hormonal abnormalities. The current study was designed to monitor hormonal changes during ovarian stimulation in an assisted reproductive technology (ART) setting. A total of 84 samples were collected: 43 from infertile women and 41 from healthy controls. Participants were selected after clinical and laboratory evaluations confirmed their respective conditions. Patients and controls ranged in age from 15 to 45 years. The mean age was 27.60 ± 4.90 years for the patient group and 27.85 ± 4.90 years for the control group. Serum concentrations of hormones pre-stimulation, such as prolactin (PRL), thyroid-stimulating hormone (TSH), anti-mullerian hormone (AMH), estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and progesterone (Proge) before ovarian stimulation were assessed during the ovarian stimulation protocol. The findings showed that the outcomes of FSH, AMH, TSH, PRL, and Proge were statistically significant (p <0.05) between infertile patients and healthy controls. In the process of examining the impact of the level of hormones on the female groups of ages, the age was grouped into four categories; the first category was those whose age was below 30 years, the second category was those whose age was between 30 to 35 years old, the third category was those whose age was between 36 and 40 years old and the fourth category was those whose age was over 40 years old. E2 and FSH were only statistically significant (p < 0.01) in all age groups of patients and controls. Besides the level of serum hormones following ovarian stimulation, the level of hormones in infertile and fertile women was also determined to obtain the median level of hormones before and after stimulation, according to age group. The outcome of E2 was significant (p < 0.01). The article concludes that the variation in hormonal levels of FSH and E2 is a significant measure of infertility and ovarian response to stimulation. Age has a profound influence on these variances, and the need for hormonal assessment to be individualized in the context of fertility management.