Relationship between Oxidative Stress and Inflammation in Ankylosing Spondylitis

Abstract

     Ankylosing spondylitis (AS) is a chronic inflammatory disorder in the vertebral spine and sacroiliac joints. The assessment of systemic oxidative stress has been accurately linked to the pathogenesis of various illness processes, including AS. The relationship among oxidant and antioxidant stress biomarkers in AS was investigated, and their possible contribution to its pathogenesis was determined. The research included 80 patients diagnosed with AS, along with 48 healthy volunteers. Serum levels of total antioxidant status (TAS) and total oxidant status (TOS) were measured using Erle's method, and the oxidative stress index (OSI) and other routine tests were calculated. Serum TOS, OSI, CRP, and ESR values were found to be significantly elevated in patients compared to healthy controls (HCs) (P < 0.01). Conversely, serum TAS levels were found to be reduced in patients (P < 0.01). These variables are considered critical in the pathogenesis of AS, where they contribute to its diagnosis and management.