Assessment the Immunohistochemical Expression of Cathepsin D in Iraqi Patients with Colorectal Carcinoma

Ban   Mohamad; Khawla   Zghair; Faeza   Zghair; Reyadh   Mohammed

doi:10.24996/ijs.2015.56.4c.%g

Authors

Ban Mohamad Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq
Khawla Zghair Department of Biology, College of Science, University of Baghdad. Baghdad-Iraq.
Faeza Zghair Ibn-Sina College of Medicine, Al-Iraqia University, Baghdad, Iraq
Reyadh Mohammed Department of Biology, College of Science, University of Tikrit, Tikrit, Iraq

DOI:

https://doi.org/10.24996/ijs.2015.56.4c.%25g

Keywords:

Immunohistochemical , Cathepsin

Abstract

In the current study hundred ten of Iraqi patients with colorectal tumors were studied to evaluate the expression of Cathepsin D using Tissue microarray-Immunohistochemisty (TMA-IHC) technique. Of them, Ninety cases had colorectal carcinoma, and twenty had benign tumors. A group of twenty cases of non-specific colitis and other twenty colonic biopsies without significant pathology were also studied. Results revealed high expression of Cathepsin D in tumors (96.7% of malignant cases, 80% of adenomas) versus 30% of colitis. As well high significant differences (P< 0.001) in the expression of CathepsinD in different tumor types (adenocarcinoma and mucinous carcinoma), tumor stages and grades.