Urokinase – type Plasminogen Activator System in Human Breast Cancer

Authors

  • Reyadh Al-Jubouri Department of Biology, College of Science, Tikrit University, Salah Al-Din, Iraq
  • Faeza Al-Rawi Ibn-Sina College of Medicine, Al-Iraqia University, Baghdad, Iraq,
  • Ali Al-Khafaji Central Public Health Laboratory, Ministry of Health.

Keywords:

Breast cancer, , uPA, , uPAR , PAI-1, Tissue microarray

Abstract

Urokinase plasminogen activator (uPA), urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1(PAI-1) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumors. This study revealed direct correlation between immunohistochemical expression of uPA with pathological stage. No significant association of immunohistochemical expressions of uPA, uPAR and PAI-1 with immunohistochemical expressions for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor -2 (HER-2/neu), and direct association between immunohistochemical expressions of (uPA and uPAR) as well as between immunohistochemical expressions of (uPA and PAI-1).

Downloads

Download data is not yet available.

Downloads

Published

2024-01-26

Issue

Section

Biology

How to Cite

Urokinase – type Plasminogen Activator System in Human Breast Cancer. (2024). Iraqi Journal of Science, 54(4Appendix), 1050-1056. https://ijs.uobaghdad.edu.iq/index.php/eijs/article/view/12418

Similar Articles

1-10 of 1154

You may also start an advanced similarity search for this article.