The Inhibitory Effect of Some Plant Extracts on Acetylcholinesterase Activity in Mice

Abstract

The results of the phytochemical analysis of the crude aqueous and
methanolicextracts of Myrtle (Myrtuscommunis), peppermint (Menthapiperita) and
Sweet basil(Ocimumbasilicum) contain active compounds : Phenols, Flavonoids and
Tannins and missing of Steroids and Coumarines in all extract but Saponins and
Alkaloids found in methanolicextract only, while terpens were present in peppermint
and basiland absent in Myrtle. Administratingto animals with different extracts
showed no effect on serum Acetylcholinesterase (AchE) compared withthese fed on
ethanol liquid diet, Methanolicand aqueous extracts of Myrtle, peppermint and
basilin the serum of decreased Acetylcholinesterase level significantly(p≤0.05)[(1.25
ΔpH/30 min, 1.23 ΔpH/30 min, 1.28 ΔpH/30 min, 1.20 ΔpH/30 min, 1.26 ΔpH/30
min, 1.28 ΔpH/30 min), liver(0.35 ΔpH/30 min, 0.34 ΔpH/30 min, 0.34ΔpH/30 min,
0.36ΔpH/30 min, 0.42ΔpH/30 min, 0.39ΔpH/30 min) and brain(0.32ΔpH/30 min,
0.37ΔpH/30 min, 0.39ΔpH/30 min, 0.36ΔpH/30 min, 0.34ΔpH/30 min, 0.37ΔpH/30
min)] respectively compared with animals fed on ethanol liquid diet [(1.37 ΔpH/30
min), (0.47 ΔpH/30 min), (0.45 ΔpH/30 min)] respectively.