Correlation between virulence factor and biofilm formation in Proteus spp.

Abstract

Urinary Tract Infection is an infection that caused by the members of the genus
Proteus that depends mainly on the availability of virulence factors ;Various
virulence factors including biofilm, swarming migration , polysaccharide
,heamolysin,protease, DNase, urease production weredetermined for 45Proteus
isolates that obtained from clinical specimens of Urinry Tract Infection patient .
The distribution of virulence factors was showed variation among the testedisolates
and strain specific in most cases. All Proteus isolates showed 45 (100%)biofilm ,
polysaccharide andSwarming capabilities with different extents. High
ureaseproduction was demonstrated in most isolates 40 (88.8%);In addition, they
were abling to produce protease,DNase and heamolysin, in 30(66.6%) , 28 (62.2%)
and26(57.7%) respectively.
The result of susceptibility test for Proteus spp. against seven antibiotics
commonly used to treat UTI infection caused by Proteus spp. ; P.mirabilis were
90% sensitive for Meropenem , 80% to Ciprofloxacin , 60% for both Cephalothin ,
Nitrofurantion , 50% , 40% and 30% for Amikicin, gentamicin and ceftriaxone
respectively ,butP.vulgaris isolates were sensitive to 80% for Meropenem ,70%
Ciprofloxacin and Nitrofurantion and sensitive to 60%,50% ,40 % and 30 % for
Cephalothin, gentamicinAmikacinand ceftriaxone respectively.(This studyaimed to
detect and evaluate the presence of some virulence factors in Proteus species
isolates causing Urinry Tract Infection