Synthesis, Identification, and Study of the Antimicrobial and Antioxidant Activities of Some New 2,5-Disubstituted-1,3,4-Oxadiazole Derivatives

Authors

  • Rana Abid Ali Department of Chemistry, College of Science, University of Baghdad, Baghdad , Iraq https://orcid.org/0000-0002-2848-4604
  • Entesar O. Al-Tamimi Department of Chemistry, College of Science, University of Baghdad, Baghdad , Iraq
  • Shatha Abdul Wadood Department of Chemistry, College of Science, University of Baghdad, Baghdad , Iraq https://orcid.org/0000-0003-1629-3488

DOI:

https://doi.org/10.24996/ijs.2024.65.9.1

Keywords:

Antimicrobial activity, Antioxidant activity, Hydrazide, 1,3,4-Oxadiazole

Abstract

This study includes the synthesis of 2,5-disubstituted-1,3,4-oxadiazole 3-12 on creatinine derivatives that have antioxidant and microbial properties. The reaction of creatinine with hydrazine hydrate in absolute ethanol was successfully achieved to afford hydrazide derivatives 1,2. The desired 2,5-disubstituted-1,3,4-oxadiazoles 3-12 were obtained by the reaction of hydrazide derivatives with different aliphatic and aromatic acid derivatives in the presence of POCl3. FT-IR and 1H NMR spectroscopy were used to determine the structures of some compounds. The antioxidant activity of compounds 8, 9, 11, and 12, and the antimicrobial activity of compounds 1, 5, 11, and 12 were tested in vitro and showed good results.

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Published

2024-09-30

Issue

Section

Chemistry

How to Cite

Synthesis, Identification, and Study of the Antimicrobial and Antioxidant Activities of Some New 2,5-Disubstituted-1,3,4-Oxadiazole Derivatives. (2024). Iraqi Journal of Science, 65(9), 4837-4844. https://doi.org/10.24996/ijs.2024.65.9.1

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