Synthesis, Characterization, and Antioxidant Screening of Some New Azo Compounds Containing Pyrazole Moiety from Metoclopramide Drug

Authors

  • Youssef Mohsen Ibrahim Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq https://orcid.org/0009-0003-5655-2955
  • Mona Ismail Khalaf Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.24996/ijs.2023.64.11.5

Keywords:

Acetylacetone, Pyrazole, Antioxidant

Abstract

     In this work, some new pyrazole derivatives were prepared through the reaction of the diazonium salt of metoclopramide with acetylacetone to give 5-chloro-N-(2-(diethylamino)ethyl)-4-((2,4-dioxopentan-3-yl) diazenyl)-2-methoxybenzamide (1) in 80% yield. Compound 1 was then reacted with some hydrazine derivatives to afford the corresponding pyrazole derivatives in 75-93% yields. Some new azo compounds (6-10) were also prepared in 77-95% yields by treatment of the diazonium salt of metoclopramide with some phenol and aniline derivatives. The prepared compounds were characterized using FT-IR and 1H NMR spectroscopy. Some of these compounds were then tested to see how well they worked as antioxidants.

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Published

2023-11-30

Issue

Section

Chemistry

How to Cite

Synthesis, Characterization, and Antioxidant Screening of Some New Azo Compounds Containing Pyrazole Moiety from Metoclopramide Drug. (2023). Iraqi Journal of Science, 64(11), 5517-5524. https://doi.org/10.24996/ijs.2023.64.11.5

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