Detection of Anti-cancer Activity of Silver Nanoparticles Synthesized using Aqueous Mushroom Extract of Pleurotus ostreatus on MCF-7 Human Breast Cancer Cell Line

Authors

  • Alaa M. Hasan Department of Biology, Collage of Science, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0003-0091-4219
  • Sura M. Abdul Majeed Department of Biology, Collage of Science, University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.24996/ijs.2024.65.4.9

Keywords:

Silver nanoparticles, Breast cancer, MCF-7cell line, Cytotoxicity, In Vitro

Abstract

     In this research, silver nanoparticles (AgNPs) were manufactured using aqueous extract of mushroom Pleurotus ostreatus. Anticancer potential of AgNPs was investigated versus human breast cancer cell line (MCF-7). Cytotoxic response was assessed by MTT assay. AgNPs showed inhibition effect at the following concentrations 12.5, 25, 50, 100 and 200 µg/ml versus MCF-7 cell line, and all treatments had a positive result. The MCF-7 cells were inhibited up to 85.14 % at the concentration 200 μg/ml of AgNPs which reduced cells viability to 14.86%, while 12.5 μg/ml of AgNPs caused 24.23% cells inhibition with reduction of cells viability to 75.77%.

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Published

2024-04-30

Issue

Section

Biology

How to Cite

Detection of Anti-cancer Activity of Silver Nanoparticles Synthesized using Aqueous Mushroom Extract of Pleurotus ostreatus on MCF-7 Human Breast Cancer Cell Line. (2024). Iraqi Journal of Science, 65(4), 1886-1894. https://doi.org/10.24996/ijs.2024.65.4.9

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