Adenosine Deaminase and Guanine Deaminase: The Potential Role in Diabetic Foot Ulcers

Abstract

     The present study explored the possible role of adenosine deaminase and guanine deaminase in diabetic foot ulcers which is considered one of the main chronic complications of diabetes mellitus. Serum adenosine deaminase, guanine deaminase, and some biochemical parameters were investigated in 54 patients with diabetic foot ulcers and 40 healthy individuals. According to our findings, adenosine deaminase and guanine deaminase activities are much higher in diabetic foot ulcer patients than in healthy individuals. A strong positive correlation was found between adenosine deaminase and guanine deaminase activities. Adenosine deaminase and guanine deaminase had 100% sensitivity and specificity for diagnosing diabetic foot ulcers, and their area under the receiver operating characteristic curve was 1.0. Kinetic study displayed significant changes in Vmax and Km between patients and healthy individuals for both adenosine deaminase and guanine deaminase. Based on results, it can be concluded that the increase of adenosine deaminase and guanine deaminase activities may negatively contribute in diabetic foot ulcers progression.