Synthesis, Characterization, Molecular Docking, and in Vitro Screening of New Metal Complexes Derived from Acyclovir Schiff Base with Ciprofloxacin Ligand

Authors

  • Sahbaa Ali Ahmed Department of Chemistry, College of Sciences ,University of Mosul, Mousal, Iraq https://orcid.org/0000-0003-4739-7546
  • Sariya Waleed Zedan Department of Chemistry, College of Sciences ,University of Mosul, Mousal, Iraq

DOI:

https://doi.org/10.24996/ijs.2023.64.12.1

Keywords:

Acyclovir, Ciprofloxacin, Schiff base Complexes, Antibacterial, Herpes Virus

Abstract

     In this work, combining acyclovir with ciprofloxacin (CCP), a new Schiff base and its metal complexes with iron (III), manganese (II), copper (II), zinc (II), and calcium (II) ions are synthesized and structurally characterized by XRD, SEM, 1H NMR, 13C NMR, FT-IR, and UV-Visible spectral techniques. Furthermore, molecular docking studies were carried out, and the complexes were tested to resolve any potential hang-ups in opposition to the Herpes virus and DFT calculation studies. In addition, the metal complexes and ligand were screened against antibacterial strains of one gram-positive bacteria (Staphylococcus aureus) and three gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumonia), and it was established that these complexes demonstrate dissimilar bustles of inhibition on the enlargement of the bacteria.

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Published

2023-12-30

Issue

Section

Chemistry

How to Cite

Synthesis, Characterization, Molecular Docking, and in Vitro Screening of New Metal Complexes Derived from Acyclovir Schiff Base with Ciprofloxacin Ligand. (2023). Iraqi Journal of Science, 64(12), 6072-6092. https://doi.org/10.24996/ijs.2023.64.12.1

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