Improving Oral Intake of Essential Oil Blends Using A Novel Formulation of Biodegradable Chitosan/Lecithin Nanoparticles

  • Israa Ali Zaidan Al-Ogaidi Department of Biotechnology, College of Science, University of Baghdad, Baghdad, Iraq
Keywords: biodegradable nanoparticles (NPs), chitosan/lecithin, antimicrobial activity, Salmonella typhi, Essential oils

Abstract

     A novel, safe and efficient method was developed to encapsulate a blend of essential oils (EOs) into biodegradable nanoparticles (NPs). The biodegradable and biocompatible nanoparticles were made from chitosan (CH) and lecithin (LE) . The quality of the essential oils was verified using gas chromatography/mass spectrometry (GC/MS). The synthesis of nanoparticles included emulsification, followed by sonication, homogenization, and extrusion. Transmission electron microscopy (TEM) indicated that the nanoparticles were spherical in shape with sizes ranging from 25 to 70 nm, while dynamic light scattering (DLS) showed high negative zeta potentials. The stability of the final formula was evaluated in gastric and intestinal fluids. The chitosan/lecithin encapsulated EOs exhibited promising antimicrobial activity against the multi-drug resistant bacteria Salmonella typhi.

Published
2021-09-30
How to Cite
Al-Ogaidi, I. A. Z. (2021). Improving Oral Intake of Essential Oil Blends Using A Novel Formulation of Biodegradable Chitosan/Lecithin Nanoparticles. Iraqi Journal of Science, 62(9), 2906-2914. https://doi.org/10.24996/ijs.2021.62.9.7
Section
Biotechnology