Determination of the Level of IL-6 and Vaspin in Hyperthyroid Patients Treated with Carbimazole

Abstract

      The level of adipokines (interleukin-6 and vaspin) in hyperthyroid patients treated with carbimazole drug was determined. Eighty-five male and female participated in this study, with mean age from 20-70 years. They included: negative control group of thirty euthyroid persons represented group 1, twenty-five hyperthyroid patient (positive control) included in the second group and thirty hyperthyroid patients treated with carbimazole drug for one year or less comprised the third group. By vein puncture, blood was collected, and serum was isolated and preserved at –20 C. Adipokines (interleukin-6 and vaspin) were estimated by using ELISA method. The results demonstrated that the the increase of IL-6 level was highly significant (p<0.01) in hyperthyroid group as compared with euthyroids. But the result showed a significant decrease in vaspin level in hyperthyroid group with treatment as compared with hyperthyroid group. However, there was a significant (p<0.05) decrease in the level of vaspin in hyperthyroid group with treatment in comparison to euthyroids. Also there was no significant difference in vaspin level in hyperthyroid group with treatment in comparison to hyperthyroid group. These findings suggest that the level of IL-6 increase in hyperthyroid patient and decrease after treatment with carbimazole drug for one year or less. Although vaspin level decreased in hyperthyroid patients, it  decreased even after treatment with carbimazole drug for one year or less.