Synthesis and Identification of Some Imino Chalcone Derivatives with Evaluating their Anti-oxidant Activity

  • Hala Shkyair Lihumis Department of Chemistry, College of science, University of Babylon, Iraq
  • Saadon Abdulla Aowda Department of Chemistry, College of science, University of Babylon, Iraq
Keywords: iminochalcone, 2,4-dihydroxy chalcone, aniline, antioxidant activity

Abstract

This work involves the preparation of high yield iminochalcon compounds (B1-B15)  through two parts. The first part involves the preparation of 2,4-dihydroxy Chalcone (A1-A15) by the condensation of 2,4-dihydroxy acetophenone  with  aryl aldehyde in the presence of sodium hydroxide (40%) as a catalyst. The second part includes the preparation of  iminochalcon from the condensation of p-hydroxy aniline with 2,4-dihydroxy chalcone  derivatives  )A1-A15)  in the presence of some drops of conc. H2SO4. Thin-layer chromatography ((TLC)  was used to control the chemical reaction . These new derivatives were characterized by using FT-IR and  1H-NMR spectroscopy. These synthesized compounds were also assessed by the DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free radical method, through which the compounds (B1-B15) were evaluated for their antioxidant activity. The compound B3 was found to have the strongest antioxidant activity  (IC50= 23.91 μg/mL) as compared to that of the common standard of ascorbic acid (IC50=31.95 μg/mL).

Published
2021-05-08
How to Cite
Lihumis, H. S., & Aowda, S. A. (2021). Synthesis and Identification of Some Imino Chalcone Derivatives with Evaluating their Anti-oxidant Activity. Iraqi Journal of Science, 1-16. https://doi.org/10.24996/ijs.2021.SI.2.1
Section
Chemistry