Alcoholic extract effect of Withania somnifera roots on cholesterol diet induced hyperlipidemia in male rabbits
Keywords:W. somnifera, hyperlipidemia, HMG-CoA reductase, cholesterol
The current study was used 20 male rabbits that divided into four groups (consist of five rabbits in each group), The first group was considered as control and fed normal diet and given tap water, The second group was consisted of rabbits that fed on high cholesterol diet for six weeks, The third group was consisted of rabbits that fed on high cholesterol diet and 50mg root extract for six weeks, The forth group was consisted of rabbits that fed on high cholesterol diet and 100mg root extract for six weeks. The male rabbits that feeding on high cholesterol diet showed significant increased (P < 0.05) the levels of cholesterol, triglyceride, LDL, VLDL, MDA and HMG-CoA reductase while HDL and GSH levels were significantly decreased (P < 0.05) compared with to control group. It was concluded from this study that root extract has amply good effective role on hyperlipidemia of male rabbits.