Synthesis and Characterization of Complexes Derived from Metals Mixed Ligands of Erythritol Sugar and 4-Aminoantipyrine or Salicylic acid as Antibiotic

Waseem M. Gameel  Hasan; Samaa A.  Raoof; Asem S. A. A.  Albotani; Shakir M.  Saied; Mohaned Y.  Saleh; Rania Abd Elmohsen  Abo El Nour; M. A.  Abdelzaher

doi:10.24996/ijs.2026.67.9.%g

Authors

Waseem M. Gameel Hasan Department of pharmaceutical chemistry, College of Pharmacy, Ninevah University, Mosul- Iraq https://orcid.org/0000-0001-5180-7283
Samaa A. Raoof Northern Technical University, Mosul Technical Institute, Department of Chemical Industry, Mosul, Iraq
Asem S. A. A. Albotani Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq
Shakir M. Saied College of Pharmacy, Al-Noor University, Mosul city, Alshallalat Road
Mohaned Y. Saleh Department of Chemistry, College of Education for Pure Science, University of Mosul, Mosul, Iraq
Rania Abd Elmohsen Abo El Nour Community Health Nursing Department, Beni-Suef Health Technical Institute, Ministry of Health, Beni-Suef, 62511, Egypt / Anesthesia Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, 51001, Babylon, Iraq
Abdelzaher Environmental Science and Industrial Development Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62511, Egypt

DOI:

https://doi.org/10.24996/ijs.2026.67.9.%25g

Keywords:

4-aminoantipyrine, Antibiotic activity, Erythritol, Metal complexes, Octahedral geometry, Salicylic acid

Abstract

New antibiotic complexes were synthesized from cobalt, nickel, copper, and zinc, ions mixed with ligands of either erythritol (ER) with 4-aminoantipyrine (4AAP), complexes I(a-d) or erythritol (ER) with salicylic acid (SAL), complexes II(a-d). The general formulas for these two types complexes are [M(ER)(4AAP)(H₂O)₂] and K₂[M(ER)(SAL)(H₂O)₂], respectively. These complexes were characterized by various physical properties, including melting points, colors, and solubility, alongside elemental analysis via CHN device. Additional techniques employed for characterization included molar conductance measurements, Fourier-transform infrared spectroscopy (FTIR), Ultraviolet-Visible (UV-VIS) spectrophotometry, magnetic susceptibility tests and flame absorption. Both 4-aminoantipyrine (4AAP) and salicylic acid (SAL) serve as bidentate ligands, each contributing two donor atoms to form four coordinating bonds in the structure of these mixed ligand complexes ( I and II). All synthesized complexes are non-electrolytes and are classified as octahedral. Some complexes demonstrated antibacterial potential; notably, complexes Ia and IId showed activity against E. coli at both tested concentrations, reaching 59.1% of the activity of ciprofloxacin, while their activity against Pseudomonas aeruginosa reached 58.3% and 58.4% respectively.