Investigating Interleukin-6 and Interleukin-10 in Ulcerative Colitis of Iraqi Patients: An Immunohistochemical Study

Fatimah Ahmed  Sabry; Suhad Saad  Mahmood

doi:10.24996/ijs.2026.67.7.25

Authors

Fatimah Ahmed Sabry Biotechnology Department, College of science, Baghdad University, Baghdad, Iraq https://orcid.org/0000-0002-2341-9168
Suhad Saad Mahmood Biotechnology Department, College of science, Baghdad University, Baghdad, Iraq

DOI:

https://doi.org/10.24996/ijs.2026.67.7.25

Keywords:

Ulcerative colitis, Cytokines, IL-6, IL-10

Abstract

Cytokines are immune components that serve as markers for either promoting or inhibiting inflammation, contingent upon their specific concentrations and the presence of additional modifying factors. This study evaluates the relationship between ulcerative colitis (UC) tissue and the expression levels of Interleukin-6 (IL-6) and Interleukin-10 (IL-10). This research involves the endoscopic biopsy of 35 specimens from ulcerative colitis and 15 specimens from normal colon tissue to evaluate the expression levels of IL-6 and IL-10. The immunohistochemical technique revealed that IL-6 levels were significantly elevated in patients with UC, whereas IL-10 expression was comparatively lower in these patients. The data suggest that IL-6 and IL-10 may significantly influence the progression of UC and could serve as useful biomarkers for monitoring this progression.