Synthesis, Characterization, Thermal Behavior and Antimicrobial Activities of Mixed Metal Complexes of Various Ligands For Cr+3, Mn+2, Fe+3, Co+2, Ni+2 and Cu+2 Ions

Noor M. Majeed; Imama B.N. AL-Talabanee; Ali Nabil  Niseaf; Shatha M. H. Obaid; Amer J. Jarad; Hanan Adnan Shaker  Al–Naymi; Ali M. A.  Al-Khazraji; Waleed K. Mahdi; Yahya F.  Al-Khafaji

doi:10.24996/ijs.2026.67.11.%g

Authors

Noor M. Majeed Department of Chemistry, College of Education for Pure Sciences - Ibn Al-Haithem, University of Baghdad, Baghdad, Iraq
Imama B.N. AL-Talabanee Department of Chemistry, College of Education for Pure Sciences - Ibn Al-Haithem, University of Baghdad, Baghdad, Iraq
Ali Nabil Niseaf Department of Chemistry, College of Education for Pure Sciences - Ibn Al-Haithem, University of Baghdad, Baghdad, Iraq https://orcid.org/0009-0005-1842-1211
Shatha M. H. Obaid Department of Chemistry, College of Education for Pure Sciences - Ibn Al-Haithem, University of Baghdad, Baghdad, Iraq
Amer J. Jarad Department of Chemistry, College of Education for Pure Sciences - Ibn Al-Haithem, University of Baghdad, Baghdad, Iraq https://orcid.org/0009-0006-5418-2454
Hanan Adnan Shaker Al–Naymi Department of Chemistry, College of Education for Pure Sciences - Ibn Al-Haithem, University of Baghdad, Baghdad, Iraq
Ali M. A. Al-Khazraji Department of Chemistry, College of Education for Pure Sciences - Ibn Al-Haithem, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0002-2111-3771
Waleed K. Mahdi Department of Chemistry, College of Education for Pure Sciences - Ibn Al-Haithem, University of Baghdad, Baghdad, Iraq
Yahya F. Al-Khafaji Department of Chemistry, College of Science, University of Babylon, Babylon, Iraq https://orcid.org/0000-0002-4067-9375

DOI:

https://doi.org/10.24996/ijs.2026.67.11.%25g

Keywords:

8-Hydroxyquinoline (8HQ), m-Aminophenol (A), L-Alanine (Ala), Metal complexes, Spectral analysis, Biological activity

Abstract

A series of mixed-ligand complexes were synthesized in ethanol using an equimolar (1:1:1:1) combination of 8-hydroxyquinoline, 3-aminophenol, and L-Alanine. Comprehensive characterization, including spectroscopic (FT-IR, UV-Vis, Mass), elemental (atomic absorption), and physical (conductivity, magnetism) methods, supported the assignment of an octahedral coordination geometry. The inhibition effects of ligands and their complexes at concentration of 10^-3 were studied using agar against several pathogenic microorganisms such as K. pneumoniae, E. coli, S.aureus, S.epidermidis and C.albicans. The results revealed that the ligand 8-Hydroxuquinoline (8HQ) exhibited the strongest inhibitory activity for the growth of bacteria isolated with an inhibitory diameter (45, 44, 42,42, 38) mm on the growth of E. coli, S. epidermidis, K. pneumonia, C. albicans and S. aureus respectively, and ligand L. Alanine (Ala) also demonstrated inhibitory efficacy ranging from (40 to 14 )mm. The complexes also have a clear effect, and the most effective of them was [Mn(L₁) (L₂) (L₃) (H₂O)₂Cl]Cl_2,which exhibited an inhibitory diameter of (39 and 38) mm on K.pneumonia and S. aureus_,32 mm on C.albicans, 31mm on S.epidermidis and 18mm on E.coli. Also, all complexes gave varying inhibitory activities, which are related to the growth of bacteria and fungi.