Measurement of Some Hematological and Immunological Parameters in the Sera of Asthmatic Patients

Abstract

The present study was carried out on (80) adults asthmatic patients (43 male and 37 female), their age from (25 -65) years. Some of them acute episodes while other between episodes interval.They were selected from out patients clinics of AL-Zahra'a hospital for allergy and asthma in Baghdad.All patients were diagnosed according to standard medical criteria as being asthmatic. The results of investigations were compared with those for a total of (20) healthy individual [(12) male & (8) female] with age (25 – 45) years, as a control group, throughout the period extended from ( July 2014 till December 2014).
The patient samples were applied to determine complete blood count include (Hb, PCV, RBC count, WBC & Eosinophil count) in addition to (IL-8, GM-CSF) which estimated by ELISA technique.The results revealed that the mean Hb level for asthmatic patients were lower than normal value (9.3+ 1.4 g/L, 8.7+ 1.5 g/L) male & female respectively. More ever PCV, RBC, count values for both were nearly equal with in low values (26+ 4, 3.6 + 0.3 male, 25+ 3, 3.7+ 0.35 female).
In this study the patients suffered from Iron deficiency anemia and nutritional deficiency. While leukocyte and eosinophile count values where higher than normal male: (12.5+ 0.5, 0.5 + 0.17), female: (12.6 + 0.6, 0.67 + 0.32) respectively and this due to asthmatic state.Most of sera patients had high concentration of Cytokine (IL-8& GM-CSF).The values concentration were found to be as high as (177pg/ml , 43 pg/ml) respectively in compared with healthy control (70 pg/ml , 8.2 pg/ml).