The Study of the Effect of Sodium Nitroprusside in Anxiety-Like Behavior in Mice in Comparison With Diazepam

  • Abeer Mudhafar Al-Humaidhi Department of Pharmaceutical Sciences, College of Pharmacy, Thi-Qar University, Iraq
  • Afrah Thiab Hlail Department of Pharmaceutical Sciences, College of Pharmacy, Thi-Qar University, Iraq
  • Semaa H. Shalal Department of Pharmaceutical Chemistry, College of Pharmacy, Thi-Qar University, Iraq
Keywords: anxiety, elevated plus maze, light/dark test, mice, nitric oxide, sodium nitroprusside

Abstract

Anxiety has become a highly paramount field of research attention in psychopharmacology today. Sundry studies have shown a nitric oxide role in the regulation of anxiety. The goal of the study was to investigate sodium nitroprusside ability to affect anxiety-like behavior in mice and to compare this effect with the standard anxiolytic drug, diazepam, using both plus maze test and light/dark box test. The results revealed that sodium nitroprusside at a dose of 1 mg/kg had a significant effect on the behavior in both of the elevated plus maze test and light/dark test. However, at higher dose (3 mg/kg), it has significantly increased the anxiogenic-like effect in the light/dark box test. Diazepam at a dose of 2 mg/kg increased the time spent in open arms in elevated plus maze test and that in light chambers of light/dark test. These outcomes suggest that a nitric oxide pathway seems to play an important role in anxiety. Furthermore, sodium nitroprusside at a dose of 1 mg/kg showed a nearly anxiolytic ability, when compared with diazepam.

Published
2020-03-27
How to Cite
Al-Humaidhi, A. M., Hlail, A. T., & Shalal, S. H. (2020). The Study of the Effect of Sodium Nitroprusside in Anxiety-Like Behavior in Mice in Comparison With Diazepam. Iraqi Journal of Science, 61(3), 485-490. https://doi.org/10.24996/ijs.2020.61.3.3
Section
Biology