Estimation of Tenascin-c and Thrombospondin-1 as biomarkers for cardiovascular disease in dyslipidemia patients

Hiba Abid Al-Hussein  Hassan; Hind Salman  Jassim; Shatha Hamad  Jwaid

doi:10.24996/ijs.2026.67.10.7

Authors

Hiba Abid Al-Hussein Hassan Department of Medical Laboratory Science Technology, Collage of Health &Medical Technology/Baghdad, Middle technical university (MTU), Baghdad, Iraq. https://orcid.org/0000-0002-3615-2378
Hind Salman Jassim Baquba Technical Institute- Middle Technical University (MTU), Baghdad, Iraq. https://orcid.org/0000-0002-7380-3061
Shatha Hamad Jwaid Department of Medical Laboratory Science Technology, Collage of Health &Medical Technology/Baghdad, Middle technical university (MTU), Baghdad, Iraq.

DOI:

https://doi.org/10.24996/ijs.2026.67.10.7

Keywords:

cardiac biomarker, cardiovascular disease, Dyslipidemia, tenascin-C, Thrombospondin-1

Abstract

This study aimed to evaluate Tenascin-c (TN-C) and thrombospondin-1 (TSP-1) levels in patients with dyslipidemia concerning cardiovascular disease. Numerous studies have identified TN-C and TSP-1 as biomarkers of cardiovascular disease. The study included 45 dyslipidemia patients and 45 healthy controls. The results showed significantly higher levels of Tenascin-C -C and Thrombospondin-1 in patients compared to control group, with P<0.001. Additionally, mean levels of serum Ca, serum ionized Ca, and vitamin D3 were significantly decreased P<0.001 in patients compared to controls. Positive correlation was found between Tenascin-c and Thrombospondin -1 with cholesterol and LDL, r=0.532, r=0.600, respectively, with P<0.001, while negative correlations were observed between both Tenascin-c and Thrombospondin -1with HDL, Ca, ion Ca, and vitD3 with P<0.001. The level of Tenascin-c was positively correlated with the level of VLDL. Finally, the study found that TSP-1 was a more sensitive and specific biomarker than TN-C for early diagnosis of cardiovascular disease.