SERUM CONCENTRATION OF INTERLEUKIN

Muhammed    Al-Dabagh; Kasim   Al-Mayah; Ghaneima  Muhammed; Jassem   Alkhafaji; Ali   Jawad; Mohammed   Abbas

doi:10.24996/ijs.2011.52.2.%g

Authors

Muhammed Al-Dabagh Unit of Medical Research, College of Medicine , University of Al-Nahrain. Baghdad-Iraq
Kasim Al-Mayah Unit of Medical Research, College of Medicine , University of Al-Nahrain. Baghdad-Iraq
Ghaneima Muhammed Department of Biology, College of Science ,University of Baghdad. Baghdad-Iraq
Jassem Alkhafaji Teaching Laboratories , Medical City. Baghdad-Iraq
Ali Jawad Teaching Baghdad Hospital , Medical City. Baghdad-Iraq
Mohammed Abbas Teaching Baghdad Hospital , Medical City. Baghdad-Iraq

DOI:

https://doi.org/10.24996/ijs.2011.52.2.%25g

Keywords:

ABSOLUTE, LEUKEMIA

Abstract

Interleukin-1( IL-1) and interleukin 8 (IL-8) have a major role in initiation of
immune response. These two cytokines are secreted mainly by monocyte. This study
aimed to evaluate the initiation of immune response in patients with acute
lymphoblastic leukemia. Blood samples were collected from 36 patients with ALL
(26 treated and 10 untreated ). Other 10 blood samples were collected from healthy
individuals as control group. Enzyme linked immunosorbent assay (ELISA) was
used to estimate serum concentration of IL-1 and IL-8. Absolute monocyte count in
each blood sample was determined. The study showed a significant decrease in
serum concentration of IL-1 in treated and untreated patients, whereas, serum
concentration of IL-8 and blood absolute monocyte count showed significant
increase in untreated patients. Dropping in IL-1 and elevation of IL-8 with
increasing absolute monocyte count may indicate suppression of gene expression for
IL-1 but not for IL-8.