EFFECT OF ANTIBIOTICS TREATMENT ON HUMORAL IMMUNITY IN SHEEP VACCINATED WITH B. melitensis REV.1 VACCINE

Abstract

The aim of this study was to examine the effects of different antibiotics administered intramuscularly with a different administration times on the humoral immune response resulted from intraocular vaccination with attenuated B. melitensis Rev.1 vaccine in sheep. The results showed a significant difference in the effect of different antibiotics used with a significant difference according to the administration time between 0 time, 7 and 14 days from vaccination. Oxytetracycline and amoxicillin significantly inhibit the humoral immune response when administrated at 0, 7 and 14 days of Brucella vaccination comparing with groups treated with sulphadimidine, penicillin-dihydrostreptomycin and the non-vaccinated groups while sulphamethazine – trimethoprim inhibit the humoral immune response when administrated at 0 time of vaccination comparing with groups treated with sulphadimidine, penicillin-dihydrostreptomycin and the non-vaccinated groups. The results indicate that the failure of Brucella vaccination could happen when antibiotics administered within the first 14 days after vaccination.