Estimation the levels of B-type natriuretic peptide and interleukin-35 in some Iraqi patients suffering from rheumatoid arthritis

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disorder associated with a chronic inflammatory process that can impact the joints as well as non-articular organs such as the heart, kidney, lung, digestive tract, eye, skin, and neurological system. This study was conducted at Private Nursing Hospital and Al Kadhimiya Educational Hospital, where blood samples were collected from 122 Iraqi women; seventy-fiveof them were apparently healthy controls whileforty-sevenwere patients who had long-standing RA. B-type natriuretic peptide(BNP) and interleukin-35(IL-35)wereevaluated utilizing an enzyme-linked immunoassay. Also, total cholesterol, triglyceride, andHigh-density lipoprotein(HDL)were determined using an enzymatic colorimetric method.When RApatients were compared to healthy controls, their serum levels of BNP significantly increased(p ≤ 0.001), but IL-35significantly decreased (p<0.001). In another hand, no significant differences were noted in total cholesterol, triglyceride, HDL,low-density lipoprotein(LDL)and verylow-density lipoprotein (VLDL)when the comparison between the patients with control group. It can be concluded thatelevated levels of BNP in patients with RA may increase the risk of cardiovascular disease. Moreover, IL-35 is a crucial player in the body's immune response, and its dysregulation has been implicated in the pathogenesis of rheumatoid arthritis, suggesting a complex interplay between immune function and disease development.