Exploration of antinociceptive, antipyretic and anti-inflammatory activitiesof Curcumin in male rat

Abstract

Curcumin, one of active ingredients of Curcuma spp. Roxb (Zingiberaceae) is
referred to main medicinal part in this spice. In the present study, the analgesic,
antipyretic and anti-inflammatory actions of Curcumin were investigated in male
rats. Ninety Albino male rats (110-125g) were used in this study (six animals were
used in each test for Curcumin, aspirin and Pethedine). The effects of curcumin on
nociceptive response using writhing, tail flicking and formalin tests in rats were
evaluated. The antipyretic activity in yeast-induced fever and anti-inflammatory
activity in carrageenin-induced edema in rats were examined. Administration of
curcumin significantly P<0.05 decreased the number of writhing and stretching
induced by acetic acid, and suppressed the licking activity of the late phase in
formalin test in rats. Curcumin had significant decrease P<0.05 effects on yeastinduced
fever and carrageenin-induced edema in rats. Furthermore, the ED50 from
Log dose response curve exhibited sequence order potency in formalin test, writhing
reflex and tail flick as aspirin > curcumin. Curcumin showed synergistic effect
centrally acting pethidine and peripheral analgesic aspirin. From these results it can
be concluded that curcumin possesses analgesic effect via a different mechanism
from that of aspirin and pethidine.