ESTIMATION CELL MEDIATED IMMUNITY IN SOME IRAQI PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS.

Abstract

Cell-mediated immunity was estimated in diabetic patients by evaluation a level
of CD4 and CD8 in type 1 and 2 diabetic patients. Of the 33 patients with type 1
diabetes mellitus 17 were males and 16 were females, as well as the type 2 diabetes
mellitus patients were made up of 17 males and 16 females. Both groups attend the
outpatient Clinic in the National Diabetes Center, Al-Mustansiriya University.
Besides that, the results of this study recorded that the mean of age among patients
with type 1 diabetes mellitus was 23.42 ± 4.25 y whereas mean of age among
second group was 51.27± 7.83 y with highly significant difference was noticed
between them. In addition, the result of this study indicated that duration of disease
among type1diabetic patients was 7.15± 2.55 y while 11.45± 6.49 y among second
group with highly significant difference was noticed between them. For CD4
lymphocytes, there was a highly significant decrease (P<0.001) in the percentage
means of the CD4 cells in type2 diabetic patients, as compared with type 1 diabetic
patients. For CD8 lymphocytes, there was a decrease in the percentage of these
lymphocyte in the peripheral blood of the type 2 diabetic patients, as compared with
type 1 diabetic patients with highly significant importance was recorded between
them. In conclusion, this study proved that impaired cell mediated immunity is
prevalent in type 2diabetic patients, thus the change level of cytotoxic Tlymphocytes
(CD8) and helper T- lymphocytes (CD4) might be responsible for
depressed immune response in patients with type 2 diabetes.