Synthesis and Characterization of Some Oxazolidine and Thiazolidine Derivatives and Study of their Antioxidants Activity

Wasan K.  Damdoom; Oday H. R.  Al-Jeilawi

doi:10.24996/ijs.2024.65.11.4

Authors

Wasan K. Damdoom Department of Chemistry, College of Sciences, University of Baghdad, Baghdad, Iraq / Department of Pharmaceutical Chemistry, College of Pharmacy, University of Thi-Qar , Nassiriya , Iraq https://orcid.org/0009-0007-2235-516X
Oday H. R. Al-Jeilawi Department of Chemistry, College of Sciences, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0002-4092-2072

DOI:

https://doi.org/10.24996/ijs.2024.65.11.4

Keywords:

Antioxidant, Oxazolidine, Schiff bases, Thiazolidine, 1H NMR, 13C NMR spectroscopy

Abstract

In this work, the preparation of some new oxazolidine and thiazolidine derivatives has been conducted. This was done over two steps; the first step included the synthesis of Schiff bases A₁-A₅ in 72-88% yields by the condensation of isonicotinic acid hydrazide and aldehydes. The second step includes the cyclization of derivatives A₁-A₅ with glycolic acid and thioglycolic acid to obtain the desired products, oxazolidine derivatives B₁-B₅ (44-60% yields) and thiazolidine derivatives C₁-C₅ (41-61% yields), respectively. The structure of the prepared compounds was characterized using FT-IR, ¹H NMR, and ¹³C NMR spectroscopy. Some of the produced compounds were tested for antioxidant properties.