Effects of Gel Extract from Aloe Vera Cultivated in Iraq on Blood Glucose Level and Lipid Profile in Induced Diabetic Mice

Abstract

     In Iraq; there is a great demand for handling  some epidemic diseases such as hyperglycemia and hyperlipidema through searching some medical plant extracts which the country is rich with and contains an important phytochemicals that may solve  the incidence of such cases. Aloe vera that cultivated in Iraq, is known to be rich with biological active constituents.    The aim of  the  present study; the plant gel extract was subjected  to treat an induced diabetic lab mice through injecting  streptozotocin dose with  high fatty food to elevate lipid profile before induction of the gel oral treatment of the plant. In the study results: the oral administration of A.vera gel at concentration of 300mg/kg animal weight gives a reduction in glucose level reached to 122mg/dl at the end of the experiment as well as the anti-diabetic drug Glibenclamide in a dose of  600µg/kg body weight as the glucose level decreased to 123mg/dl glucose in comparison to glucose level 250 mg/dL at zero time. Also the plant gel shows an effect on lipid profile that include cholesterol, triglycerides and High density lipoprotein levels; the A.vera  extract after 21 days treatment causes decreasing in all lipid levels; even in normal mice fed with the extract only, except the High density lipoprotein levels had no change  after the extract treatment than the  negative control.