Let R be an associative ring with identity and let M be a left R-module . As a generalization of µ-semiregular modules, we introduce an F-µ-semiregular module. Let F be a submodule of M and x∊M. x is called F-µ-semiregular element in M , if there exists a decomposition M=A⨁B, such that A is a projective submodule of and . M is called F-µ-semiregular if x is F-µ-semiregular element for each x∊M. A condition under which the module µ-semiregular is F-µ-semiregular module was given. The basic properties and some characterizations of the F-µ-semiregular module were provided.