LEVEL OF TOTAL TUMOR PROTEIN 53 IN THE SERA OFIRAQI BREAST CANCER PATIENTS

Abstract

Breast cancer is one of the most common cancers in women. It occurs when
abnormal cells in the breast divide uncontrollably and form tumors. Mutation of
tumor suppressor gene P53 is a common event in this disease.
Level of total tumor protein 53 has been estimated in fifty serologic samples of Iraqi
breast cancer patients and (50) of benign breast tumors as patients control in
addition to (50) serologic samples which belong to apparently health volunteers. All
these patients were attending to the Teaching Hospital of Baghdad and Al-Elwia
hospital during the period between October/2007 and (April) 2008. They were
diagnosed as having breast cancer by clinical and laboratory investigation as
ultrasound waves test and fine needle aspiration (FNA). In addition to TP53, some
hematological tests as hemoglobin, pocket cells volume, platelets count and white
blood cells count were occurred. The current study revealed that (22%) out of total
malignant breast cancer tumor patients were positive, while (8%) out of benign
breast tumors patients were positive for TP53. The mean value of TP53
concentration in patients with breast cancer, benign tumors, and apparently healthy
groups were (16.47 ± 31.81 pg/ml), (4.13 ± 4.94 pg/ml) and (2.27 ± 0.52pg/ml)
respectively, with significant difference between malignant and benign cases.
The evaluate TP53 test by application of Receiver Operator Characteristic (ROC)
showed that the accuracy of TP53 was (57%), however its specificity was proposed
to be (68%) in comparison with (53.33%) sensitivity.