In vivo lung injury caused by Pseudomonas aeruginosa DNA

Abstract

Noticeable inflammatory reactions in rats lungs were caused by DNA isolated
from Pseudomonas aeruginosa include infiltration of macrophages, neutrophiles and
lymphocytes. Additionally, fibromuscular hypertrophy of smooth muscles in
respiratory bronchiols was seen as well. Since lung homogenate shows no bacterial
growth in all samples. Consequently, these inflammatory signs were attributed to
DNA effect rather than any other cause. In conclusion, apart from live bacteria, P.
aeruginosa DNA has the ability to cause inflammatory response in rat model
airways.