SYNTHESIS AND IDENTIFICATION OF SCHIFF BASES AND BILOGICAL ACTIVITY NEW STUDY

Hameed Essa; Farouk Kandil; Ahmad Falah

doi:10.24996/

Authors

Hameed Essa Department of Chemistry, College of Science, University of Damascus. Damascus – Syria.
Farouk Kandil Department of Chemistry, College of Science, University of Damascus. Damascus – Syria.
Ahmad Falah Department of Chemistry, College of Science, University of Damascus. Damascus – Syria.

DOI:

https://doi.org/10.24996/

Keywords:

Open Schiff base,, Macrocyclic, , Salicylaldehyde, , Spectral Technique,, Antimicrobial Activity.

Abstract

In this work we focused on the synthesis of new Open Schiff bases which were
prepared by condensation of salicylaldehyde with both 4,4'-diaminodiphenyl
methane,4,4'-diamino diphenyl sulphide,and by condensation of O-vanilin with
diethyl ester of terephthalic acid respectively.Also new macrocyclic Schiff Bases
were prepared by condensation of 1,6-bis(2-formylphenyl)hexane with
thiocarbohydrazid.The Schiff bases were checked by different spectral technique
(LC-MS, 1H-NMR, IR). The work was extended to study the effect of the prepared
compounds on four different bacteria in order to test there biological activity