Theoretical Study of Improving Radiotherapy at High Energies (2-15) MeV for Lung Cancer using Nanocomposites

Abstract

In this research shows how radiation therapy can be improved and developed using different structures of glucose molecules (α‐D glucose) C₆H₁₂O₆ and C₁₂H₂₄O₁₂ after adsorption on silver nanoparticles-AgNPs surface. This is by enhancing the radiation sensitivity (SER) of cancer cells in the human lung and meanwhile preserving the healthy cells surrounding the tumour itself. The primary role of AgNPs is as radiosensitizers that work to increase the absorbed dose of radiation in the presence of nanocomposites. Using a mathematical model to calculate the number of cancer cells remaining when exposed to radiation doses, where radiation sensitivity of C₆H₁₂O₆Ag₃ and C₁₂H₂₄O₁₂Ag compounds were calculated theoretically. It was found that the C₆H₁₂O₆Ag₃ compound SER increases upon an increase in the absorbed dose of radiation. It equals 15.6 at the maximum energy value of (15MeV). Increasing radiation sensitivity values is accompanied by a decrease in the number of radiotherapy sessions by half. This is considered a noticeable improvement in radiotherapy. However, with the C₁₂H₂₄O₁₂Ag configuration, SER values were found to be 12.9 at the maximum energy value. This value corresponds to a decrease in the number of radiotherapy sessions. Consequently, the C₆H₁₂O₆Ag₃ molecule structure could be the best radiosensitizer in cancer treatment.