Study the Effect of Hyperthyroidism on Heart Function by Using BNP as Indicator

Abstract

The aim was made to specify the effect of hyperthyroidism on B-type natriuretic
peptide (BNP) level. Twenty patients with hyperthyroidism, 20 patients with
hyperthyroidism treated with (35) mg Carbimazole, 12 patients with
hyperthyroidism associated with heart failure and 20 healthy participants were
included in this study. Serum Triiodothyronine (T3), Thyroxin (T4) and Thyroid
stimulating hormone (TSH) have been used for hyperthyroidism diagnosis test, also
serum BNP level was measured. The results showed that the mean ± SE of serum
BNP was significantly (P<0.05) increased in hyperthyroid group (420.76 ± 83.43)
pg/mL and hyperthyroid with heart failure group (728.58±149.06) pg/mL when
compared with the control group (23.18 ±10.10) pg/mL. While, no significant
(P>0.05) differences between hyperthyroid treated with (35) mg carbimazole group
(65.00 ± 16.21) pg/mL and control group (23.18 ±10.10) pg/mL. But, there was a
significant (p<0.05) decrease in serum BNP level in hyperthyroid treated with (35)
mg carbimazole group when compared with the hyperthyroid group and
hyperthyroid with heart failure group. The present study demonstrated that the
hyperthyroidism may lead to impaired heart function, and thus the high level of the
BNP hormone